71 companies, largest first.
Ticker Mkt Cap
LLY
Eli Lilly and Company
$1.14T
JNJ
Johnson & Johnson
$625.97B
ONC
BeOne Medicines Ltd. - American Depositary Shares
$530.90B
ABBV
AbbVie Inc.
$441.74B
MRK
Merck & Company, Inc. Common Stock (new)
$321.84B
ABT
Abbott Laboratories
$191.16B
PFE
Pfizer, Inc.
$151.64B
VRTX
Vertex Pharmaceuticals Incorporated
$134.28B
BMY
Bristol-Myers Squibb Company
$129.95B
REGN
Regeneron Pharmaceuticals, Inc.
$82.41B
TEVA
Teva Pharmaceutical Industries Limited American Depositary Shares
$42.52B
ZTS
Zoetis Inc. Class A
$31.13B
ALNY
Alnylam Pharmaceuticals, Inc.
$29.57B
INSM
Insmed Incorporated
$28.96B
RPRX
Royalty Pharma plc - Class A Ordinary Shares
$25.49B
ROIV
Roivant Sciences Ltd. - Common Shares
$25.46B
UTHR
United Therapeutics Corporation
$22.09B
VTRS
Viatris Inc.
$18.68B
BBIO
BridgeBio Pharma, Inc.
$16.40B
JAZZ
Jazz Pharmaceuticals plc - Ordinary Shares
$16.09B
BMRN
BioMarin Pharmaceutical Inc.
$13.46B
ARWR
Arrowhead Pharmaceuticals, Inc.
$12.60B
MDGL
Madrigal Pharmaceuticals, Inc.
$12.36B
CORT
Corcept Therapeutics Incorporated
$12.09B
SMMT
Summit Therapeutics Inc.
$12.06B
ELAN
Elanco Animal Health Incorporated
$11.37B
AXSM
Axsome Therapeutics, Inc.
$11.11B
CYTK
Cytokinetics, Incorporated
$10.63B
PRAX
Praxis Precision Medicines, Inc.
$10.35B
PTGX
Protagonist Therapeutics, Inc.
$9.58B
IONS
Ionis Pharmaceuticals, Inc.
$9.21B
SYRE
Spyre Therapeutics, Inc.
$9.06B
CRNX
Crinetics Pharmaceuticals, Inc.
$8.95B
ALKS
Alkermes plc - Ordinary Shares
$8.25B
LQDA
Liquidia Corporation
$7.83B
TGTX
TG Therapeutics, Inc.
$7.64B
COGT
Cogent Biosciences, Inc.
$6.62B
MIRM
Mirum Pharmaceuticals, Inc. - common stock
$6.38B
ORKA
Oruka Therapeutics, Inc.
$6.31B
PTCT
PTC Therapeutics, Inc.
$6.15B
XENE
Xenon Pharmaceuticals Inc. - Common Shares
$6.12B
DNTH
Dianthus Therapeutics, Inc.
$6.07B
KNSA
Kiniksa Pharmaceuticals International, plc - Class A Ordinary Shares
$5.95B
LGND
Ligand Pharmaceuticals Incorporated
$5.76B
ERAS
Erasca, Inc.
$5.69B
TVTX
Travere Therapeutics, Inc.
$5.68B
DFTX
Definium Therapeutics, Inc. - Common Shares
$5.49B
ACAD
ACADIA Pharmaceuticals Inc.
$5.07B
DYN
Dyne Therapeutics, Inc.
$4.99B
MANE
Veradermics, Incorporated
$4.55B
INDV
Indivior Pharmaceuticals, Inc.
$4.53B
VKTX
Viking Therapeutics, Inc.
$3.94B
QURE
uniQure N.V. - Ordinary Shares
$2.84B
AMLX
Amylyx Pharmaceuticals, Inc.
$2.64B
BHC
Bausch Health Companies Inc.
$2.33B
VERA
Vera Therapeutics, Inc. - Class A
$2.18B
SLS
SELLAS Life Sciences Group, Inc.
$2.05B
AGIO
Agios Pharmaceuticals, Inc.
$1.95B
SRPT
Sarepta Therapeutics, Inc.
$1.92B
MNPR
Monopar Therapeutics Inc.
$765.0M
BIOA
BioAge Labs, Inc.
$489.7M
GSK
GSK plc American Depositary Shares (Each representing two Ordinary Shares)
AZN
AstraZeneca PLC Ordinary Shares
ASND
Ascendis Pharma A/S - Ordinary Share
ABVX
Abivax SA - American Depositary Shares
NVO
Novo Nordisk A/S
SNY
Sanofi - American Depositary Shares
NVS
Novartis AG
TAK
Takeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock)
LEGN
Legend Biotech Corporation - American Depositary Shares
GMAB
Genmab A/S - American Depositary Shares

About Pharmaceutical Stocks

Big pharma is a defensive sector with a hole in it. The dividends are reliable, the balance sheets are strong, and the cash flows are enormous, right up until a patent expires and a drug that was most of the profit gets copied for a fraction of the price.

That expiry is the only thing worth planning around, and it is on a published date. Every one of these companies is in a permanent race to replace revenue it is about to lose, either by discovering something or by buying whoever did. This is why the sector consolidates constantly and why an acquisition here is usually a confession about the pipeline.

Prices are the political risk. These are not businesses that set their own prices; insurers and government programs negotiate them, and any serious drug pricing reform lands directly on the margin. The group tends to be cheap relative to the market for exactly that reason. Clinical-stage developers filed alongside them are a different instrument entirely, with no revenue, a cash balance, and a binary trial result that can halve or double the stock in a morning.

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